Retatrutide (LY3437943) is a single-peptide agonist of glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and glucagon receptors with substantial metabolic efficacy but an incompletely characterised psychological phenotype. This paper evaluates its plausible effects on executive control, information processing, food-directed cognitive interference, motivational salience, fatigue, and psychophysiological vigor. A structured evidence synthesis covered literature from 2010 through 10 August 2026 and separated direct retatrutide findings from receptor-level and broader cognitive-neuroscience evidence.
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